Welsh Anaesthetic Trainees Journal Club

Journal Club: 28th March 2018

Poor performance in incremental shuttle walk and cardiopulmonary exercise testing predicts poor overall survival for patients undergoing esophago-gastric resection

European Journal of Surgical Oncology 2018 j.ejso.2018.01.242

 Presented by: Dr T Green


Patients with oesophageal and gastric cancer have a poor prognosis with an untreated five year survival at time of diagnosis of 20% and an increase to only 40% following treatment.  It can take up to one year for many patients to recover from treatment and regain their preoperative quality of life and many patients will not achieve this.  Careful preoperative assessment is essential to select those who will benefit from surgical treatment.

The Incremental Shuttle Walk Test (ISWT) and Cardiopulmonary Exercise Testing (CPET) can be used to assess the preoperative fitness of patients.  CPET results include the Anaerobic Threshold (AT) and Maximal Oxygen Consumption (VO2 Max).  This study aims to assess the correlation between ISWT and CPET with postoperative survival and postoperative pulmonary complications.

Design & Setting

Observational study of patients undergoing surgery for gastric or oesophageal cancer with or without neoadjuvant chemo-radiotherapy between 2010 and 2014 (presumably at Royal Marsden Hospital / St Mary’s Hospital, London – not stated but based on authors’ affiliations)

Data collected on preoperative clinical stage, postoperative pathological stage, postoperative respiratory complications, all-cause mortality and mortality due to disease recurrence.


81 patients assessed through the Perioperative Enhanced Recovery Protocol between 2010 and 2014.  All patients underwent either ISWT or CPET (or both).


Observational study – no intervention.


  • Assessment of the utility of the ISWT and CPET for determination of postoperative respiratory complications and mortality.
  • ISWT score of 350m or above.
  • CPET values: AT 11 or above and VO2 Max 14ml/kg/min or above.


  • 73 of 81 patients (90%) had both ISWT and CPET assessment.
  • No correlation between single time point ISWT or CPET results and postoperative respiratory complications.
  • A subset of patients (45) had ISWT both before and after chemoradiotherapy and of these, those who achieved a >10% increase in score were noted to have a reduced incidence of postoperative respiratory complications (19% in those whose ISWT score improved >10% vs 45% in those whose score remained within 10% of their pre-chemoradiotherapy score or whose score reduced by >10%). This did not reach statistical significance (p = 0.08).  There was no correlation between such improvement in ISWT score and overall mortality.
  • All cause mortality and mortality due to disease recurrence correlates strongly (p < 0.001) with ISWT score ≥350m, AT ≥11 and VO2 Max ≥14 (Median survival with ISWT <350m or VO2 Max <14 was 20 months vs >5 years. Median survival with AT <11 21 months vs >5 years.)


ISWT assessment before and after chemotherapy is indicated and a reduction in score indicative of deconditioning, should trigger patient-specific exercise-based intervention.  CPET, being considerably more complicated and expensive, should be reserved for cases with established cardiopulmonary comorbidities.


  • Goals and methods clearly defined.
  • Negative results reported.
  • Recognition of limitations of current study.


  • Observational study therefore no case-control analysis.
  • Small sample size, especially for those undergoing ISWT before and after neoadjuvant chemoradiotherapy leading to underpowered statistical analysis.
  • The concurrent study being performed by the authors assessing the introduction of patient-specific exercise-based prehabilitation appears to have preceded the results of this study and may introduce bias into the analysis and conclusions.


ISWT may be a cheaper, less complicated method of determining cardiopulmonary fitness prior to surgery for gastric or oesophageal cancer and may be of use in guiding the multidisciplinary team in determining the best course of action for a given patient (surgery or conservative management).

Potential for impact

The use the ISWT, a cheaper, simpler assessment of cardiopulmonary fitness versus CPET is attractive as long as this can reasonably be used to guide treatment options.  The use of CPET still has its place based on the results of this study.

Journal Club: 21st March 2018

Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants

Critical Care 2017;21:32 doi:10.1186/s13054-017-1619-z

Presented by: Dr B Eagle


  • The use of direct oral anticoagulants (DOAC) is increasing, yet there is no way to point of care test coagulation in patients taking these drugs.
  • Haemochron signature is a coagulation point of care test (POCT) that is sensitive to rivaroxaban and dabigatran, although its action on apixiban is unreported.
  • This study aims to evaluate the use of haemochron in guiding emergency treatment of DOAC treated patients.

Design & Setting

  • Prospective observational single centre study based in Tubingen Germany.
  • Patients enrolled receiving first dose of apixiban, rivaroxaban or dabigatran.
  • Patients excluded with any form coagulopathy or on other anticoagulants.
  • 60 patients enrolled.
  • Samples of blood taken from each subject before DOAC intake and at intervals up to 24 hours post ingestion.
  • Bedside POCT testing using Haemochron was undertaken – PT/INR, aPTT, ACT.
  • Lab anti 10a concentrations were measured and liquid chromatography with mass spec used to determine concentrations as a gold standard.
  • Analyses used to determine whether POCT can determine concentrations considered safe for emergency surgery and for stroke thrombolysis i.e. POCT PT of 1 equates to concentration of 30ng/ml for rivaroxban – considered the safe threshold for operations.


  • Correlation between POCT and apixiban concentrations were weak for PT/INR and moderate for ACT.
  • No correlation for aPTT.
  • Rivaroxaban correlation strong for PT/INR and ACT and weak for aPTT.
  • Dabigatran correlated strongly with all assays.


  • Hemochron POCT testing correlates with rivaroxaban and dabigatran concentrations but not apixiban concentrations.
  • POCT specific cut offs can be used to exclude rivaroxaban concentrations at the bedside with high specificity.


  • Good sample numbers
  • Novel idea, to help with a clinically relevant problem


  • Essentially a lab study – using whole blood – tests not been used to actually guide any clinical intervention
  • This study does not help to determine what the clinically relevant concentrations of these drugs are – even though it can test for arbitrarily determined levels
  • Study does not discuss how Haemochron differs in effectiveness from established POC testing such as TEG or ROTEM

Implications & Potential for Impact

  • Haemochron signature could be used to rule out relevant concentrations of rivaroxaban and dabigatran.
  • May allow concentration based cut offs for operating on patients on DOACS to be used rather than time based cut offs currently used – time based estimation may be very variable




Journal Club: 7th March 2018

Postoperative nausea and vomiting after oral and maxillofacial surgery: a prospective study. Dobbeleir M, De Coster J, Coucke W, Politis C.

International Journal of Oral and Maxillofacial Surgery 2018 doi:10.1016/j.ijom.2017.11.018

Presented by: Dr A Phillips


  • Post-operative nausea and vomiting (PONV) is common after general anaesthesia
  • PONV leads to longer hospitalisation, higher costs, lower patient satisfaction
  • Risk scores (e.g. Apfel) exist but limited data on maxillofacial surgery (OMFS) as a risk factor for PONV
  • This study aimed to identify which types of OMFS are more related to PONV

Design & Setting

  • Single centre observational study
  • Participants categorised into bleeding risk based on type of surgery
  • PONV score calculated pre-op and anaesthetic tailored to minimise PONV
  • Anaesthesia non-standardised. Sevoflurane/desflurane/Propofol Target-controlled infusion (TCI) all used and non-standardised anti-emetic use.
  • Online questionnaire completed at day 3 post-op to determine if the patient had PONV


  • 308 patients age between 8 to 87 years undergoing general anaesthesia for OMFS
  • Exclusion: cancer cases requiring post-operative high dependency unit care (HDU)


  • A variety of maxillofacial surgeries from dental extractions to osteotomy


  • Primary outcome was self-reported post-operative nausea and vomiting questions (multiple choice answers) in the 3 days after surgery via an online questionnaire.


  • 46.1% post-op nausea (PON) and 21.1% post-op vomiting (POV) overall
  • PON statistically significantly higher in the bimaxillary surgery (BIMAX)/ bilateral sagittal split osteotomy (BSSO) groups versus “other minor surgery” and dental extraction groups (P <0.05)
  • Similar pattern between POV groups but no statistical difference between BSSO and “other minor surgery” group


  • Maxillary surgery and BSSO procedures induced significantly more PONV than the other OMFS procedures. These could be included as a parameter in the calculation of the Apfel score.
  • Significantly less PON in anaesthesia maintained with sevoflurance vs. Propofol TCI


  • An original study
  • Highlights limitations in pre-operative PONV scores


  • Observational study
  • Small sample groups
  • Not specified whether elective/emergency surgery
  • No standardisation of anaesthetic or antiemetic use – higher PONV in Propofol TCI group is contrary to widespread evidence – suggests reverse causation
  • Blood loss hypothesised as contributory factor toward PONV – no quantification of blood loss
  • Ingestion of blood hypothesised as contributory factor toward PONV – no mention of the use throat packs
  • Retrospective questionnaires are subject to recall bias


  • Based on this study, we should consider patients undergoing BSSO/maxillary surgery to be at higher risk of PONV and alter anaesthetic practice accordingly

Potential for impact

  • I don’t think it likely that practice would change based on this article. After all, one of the implications would be to avoid TIVA in those at higher risk of PONV!
  • The article highlights the higher overall risk of PONV in more complex OMFS cases but does little to convince the reader that the surgeries themselves are independent risk factors for PONV.

March 2018

Written by: Dr T Green, CT3 Anaesthetics, Morriston Hospital, Swansea

SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain. Order BA, Suresh S, Evers AS.

Anesthesia & Analgesia 2018 doi: 10.1213/ANE.0000000000002833

In December 2016, the US Food and Drug Administration (FDA) issued a Drug Safety Communication about the potential for neurotoxicity from anaesthetic agents on the developing brain of young children and foetuses.  SmartTots is a public-private partnership between the International Anaesthesia Research Society and the US FDA.  SmartTots work in collaboration with researchers to investigate such potential neurotoxicity from anaesthetic drugs.

This special article provides an update to the current understanding with a brief discussion of two clinical trials partially sponsored by the SmartTots collaboration, one completed and one ongoing.  There is then a brief discussion of recent epidemiological studies, paving the way for the upcoming conclusion of the TREX trial.

The first SmartTots sponsored trial is the General Anaesthesia Compared to Spinal Anaesthesia trial.  This aims to compare scores on an Intelligence Quotient (IQ) test measured at five years of age, comparing children undergoing surgery with general anaesthesia to those receiving a regional anaesthetic technique.  The secondary outcome of performance differences at the age of two years is available and encouragingly shows performance deficit when comparing the two groups.  The primary outcome will be available later in 2018.

The second SmartTots sponsored trial was the Pediatric Anesthesia and Neurodevelopment Assessment Study, an observational cohort design with the primary outcome to assess neurocognitive performance and behavioural outcomes in children aged eight to fifteen years, who underwent hernia repair before three years of age compared to the performance of their unexposed siblings.  The results did not support an adverse effect of anaesthetic agents on the assessed parameters.  Given the short duration of anaesthesia for a hernia repair operation, these results are felt to be in keeping with preclinical data indicating the safety of short (less than two hours) exposure to anaesthetic drugs.

An epidemiological study independent of SmartTots examined the performance of children on a primary school entrance exam, finding no performance deficit in children undergoing general anaesthesia when aged less than two years compared to age matched controls.  Interestingly in contradiction to other preclinical and clinical studies, there was a small performance deficit in children aged greater than two years when undergoing general anaesthesia.

A second epidemiological study compared overall school grades and military conscription IQ tests between those undergoing general anaesthesia on at least one occasion before the age of four years.  The results were similar for one exposure to general anaesthesia and for multiple exposures, with a small reduction in school grades and military conscription IQ tests scores although no details of duration of general anaesthesia or agent used is available.

A Study to Compare the Long-term Outcomes After Two Different Anaesthetics (TREX) Trial is an ongoing trial comparing neurodevelopmental outcomes after anaesthesia for surgery with low dose sevoflurane in combination with remifentanil and dexmedetomidine versus standard sevoflurane-based anaesthesia with anaesthetic duration of at least two and a half hours.

A description of preclinical evidence for the neurotoxicity of anaesthetic agents on the developing brain is given but is covered in the summary of “Long-term neurocognitive outcomes following surgery and anaesthesia in early life.”

This article is intended as a brief update to the current evidence in the debate over the safety of general anaesthesia in young children with immature brain physiology.  It is encouraging that clinical trials have not demonstrated a significant deficit in neurocognitive or neurodevelopmental parameters following exposure of the developing brain to anaesthetic agents.  The mainstream media and tabloids were avidly reporting the potential for harm from general anaesthesia to the developing brain when the FDA Drug Safety Communication was released and the studies summarised in this update are helpful in counselling parents of young children who need to undergo anaesthesia for surgery.

Long-term neurocognitive outcomes following surgery and anaesthesia in early life. Hansen TG, Engelhard T.

Current Opinion in Anaesthesiology 2018 doi:10.1097/ACO.0000000000000577

Controversial and alarming warnings about the potential for harm to the developing brain from exposure to anaesthetic agents have been given, such as the US Food and Drug Administration Drug Safety Communication.  These have been largely based on preclinical animal studies.  This brief review assesses these preclinical studies alongside the results of some human studies.

Preclinical animal studies including nonhuman primates have indicated an association between exposure to anaesthetic agents and neuroapoptosis and abnormal synaptic development, leading to neurocognitive impairment.  The studies seem to implicate all classes of general anaesthetic agent.

In the preclinical animal studies, the anaesthetic technique is markedly different to that employed in clinical practice.  Multimodal monitoring techniques and airway management are technically difficult or impossible to implement on neonatal small animals and therefore such monitoring and management as would be standard in clinical practice was not implemented, leading to likely hypoventilation, hypoxia and hypotension.  This is reflected in the (unreported) excessively high mortality of the animal subjects.  It is widely accepted that physiological derangements such as hypoxia and hypotension can be detrimental to the central nervous system and the studies have no mechanism for excluding this as the cause of observed neurocognitive deficits.

Studies to date are unable to pick apart the likely complex interplay of the exposure to anaesthetic agents, the stress response to surgery and the effects of the underlying condition necessitating surgery.

Also reviewed are human trials examining the neurocognitive and behavioural effects of anaesthetic exposure to the immature brain.  These are discussed further in “SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain”.  In essence, there is no convincing evidence of a clinically significant detrimental impact of anaesthetic agent exposure on neurocognitive and behavioural outcome in later life.

Providing surgery without anaesthesia would be ethically unacceptable and therefore the risks of delaying surgery (and therefore anaesthetic exposure) needs to be balanced against the potential risks from such anaesthetic exposure.  The evidence provided so does not justify a change to current clinical practice.  We should however be prepared to be asked about this topic by concerned parents of children requiring surgery.

*These two articles follow on from articles reviewed in the journal watch of January 2017 and April 2017. This is a topic that is unlikely to disappear soon given the coverage in mainstream and tabloid media.

Cognitive decline in the middle-aged after surgery and anaesthesia: results from the Wisconsin Registry for Alzheimer’s Prevention cohort

Bratzke LC, Koscik RL, Scheming KJ et al. Anaesthesia 2018 doi:10.1111/anae.14216

Recent interest has been seen in the neurocognitive effects of surgery and anaesthesia on children and the elderly.  The middle-aged however have been assumed to be non-susceptible to such effects and Patel et al (Anaesthesia 2016 71: 1144-52) when assessing cognitive decline in the elderly following anaesthesia and surgery state “A younger cohort would be unlikely to show any effect, since very few would be cognitively impaired before surgery”.

In this study, the authors conduct a prospective longitudinal cohort study to assess the effect anaesthesia and surgery may have on neurocognitive parameters in the middle-aged with no neurocognitive deficit at baseline.  Participants were sought from the Wisconsin Registry for Alzheimer’s Prevention (WRAP).  Serial psychometric analysis was performed at baseline, five years and nine years.  Patient-reported procedures in the intervening periods between psychometric testing were explored in further detail by analysis of healthcare records (anaesthetic charts, operation notes and discharge summaries).

964 candidates were included in this study with 212 having surgery before the first cognitive assessment and 130 having surgery before the second cognitive assessment.  The mean age at baseline was 54 years.

The findings were a decline in immediate memory in participants undergoing one or more surgeries during the study with an association noted between number of surgeries, cumulative duration of anaesthesia and surgery and the American Society of Anesthesiologists (ASA) physical grade.  No difference in working memory or executive function were identified.  The decline in immediate memory, while statistically significant, is of questionable clinical importance, being sufficiently small so as to not qualify as mild cognitive impairment or dementia.

This study does exhibit limitations, some of which are recognised by the authors.  Reliance on patient reporting of relevant surgical procedures may lead to omission of some relevant procedures with subsequent skewing of the results.  The surgery, although heterogenous in nature was controlled in that intracranial procedures and those requiring cardiopulmonary bypass (both directly linked to neurocognitive changes) were excluded.  Importantly however the type of anaesthesia was heterogenous, with general anaesthesia and neuroaxial or regional techniques combined together with no subgroup analysis reported.  Retrospective analysis of the study power showed 80% power and this combined with the small effect noted, leaves the question of cognitive decline in the middle-aged after surgery and anaesthesia unanswered.

Comprehensive geriatric assessment for older people admitted to a surgical service (Review). Eager G, Taheri A, Chen S et al.

Cochrane effective practice and organisation of care group 2018 doi:10.1002/14651858.CD012485.pub2

Comprehensive Geriatric Assessment (CGA) is a multidisciplinary diagnostic process utilising medical, psychosocial and functional assessment to develop an individualised management plan for older people.  Members of the multidisciplinary team include geriatric assessment trained physicians, nursing staff, physiotherapists and occupational therapists.  Previous research has shown it to be effective in both internal medicine and orthogeriatric patients.

Given the ageing population and the estimate that more than fifty percent of surgery is performed on those aged over sixty five years, mechanisms to improve overall care and outcomes from surgery in older people is of extreme importance.

This Cochrane systematic review aims to assess the use of CGA in the surgical population.  The primary outcomes were mortality and discharge to an increased level of care compared to baseline.  Secondary outcomes were length of stay, readmission rate, postoperative complications and total cost of care.  Subgroup analysis was performed to assess:

  • Orthopaedic vs other surgical specialties
  • Timing of CGA (preoperative vs postoperative)
  • Emergency vs elective surgery

Eight randomised trials were included in the systematic review, representing 1843 patients overall.  Of the eight trials, seven were specific to hip fractures and one was specific for elective oncology surgery.

Primary outcome results are reported as orthopaedic surgery alone or combined with the solid tumour surgery trial.  Mortality was reduced in hip fracture surgery but this was largely mitigated when elective oncology surgery was included.  Discharge to an increased level of care was reduced in patients undergoing surgery for hip fractures however inclusion of elective oncology surgery patients resulted in little to no effect on length of stay.

Secondary outcome results showed marked heterogeneity for length of stay but an overall small reduction was found.  No change in the rate of readmission was found but only two orthopaedic trials and one elective oncology surgery trial reported this measure, with relatively small numbers of patients overall.  Cost analysis was limited as only a single study reported this.  There appears to be a modest reduction in total cost at one year follow-up (€59,486 standard care vs €54,332 CGA).  Postoperative complications were not amenable to systematic review due to differing ways of reporting these.

Subgroup analysis is reported above for orthopaedic vs other surgical specialties.  Post-operative CGA was found to probably reduce mortality and length of stay compared to standard care but the confidence interval crosses 1.  No assessment of emergency vs elective surgery was made.

Overall, this systematic review provides evidence that CGA provides reductions in mortality and length of stay in hip fracture patients but is unable to generalise these findings to other orthopaedic procedures or non-orthopaedic surgery due to the paucity of studies.  As such, this systematic review is unable to answer the intended question – does Comprehensive Geriatric Assessment improve the outcome after admission to surgical services?  Further research is needed to extend the variety of trials in non-hip fracture orthopaedic surgery and non-orthopaedic surgery.

Preoperative versus postoperative ultrasound-guided rectus sheath block for improving pain, sleep quality and cytokine levels in patients with open midline incisions undergoing transabdominal gynaecological surgery: a randomized-controlled trial. Feng Jin, Zhe Li, Wen-fei Tan, Hong Ma, Xiao-qian Li and Huang-wei Lu.

BMC Anesthesiology 2018, 18:19 doi: 10.1186/s12871-018-0485-9

Rectus Sheath Block (RSB) is a commonly used, effective and safe analgesic technique for midline incisions for surgical procedures.  It is commonly performed preoperatively and has been shown to reduce the intraoperative anaesthetic requirements.  It has been suggested however that improved results may be evident with postoperative RSB as this will prolong the duration of action of the local anaesthetic, with improved analgesia.

This study aimed to examine preoperative versus postoperative RSB with specific regards to time to first use of patient-controlled analgesia (PCA) pump, total dose of opioid analgesic required using the PCA pump, levels of inflammatory cytokines (Interleukin-6 / IL-6, Interleukin-1β / IL-1β, Interferon-γ / IFN-γ, Tumour Necrosis Factor-α / TNF-α) measured by serial venepuncture and sleep quality assessed using Bispectral Index (BIS) monitoring (elevated IL-6 has been associated with reduced sleep quality).  Several studies have been performed validating the use of BIS monitoring on depth of natural sleep (e.g. Giménez et al 2017, J Clin Monit Comput.  Doi 10.1007/s10877-015-9805-5)

Sixty four patients undergoing elective non-cancer open abdominal gynaecological surgery were randomised to either receiving preoperative RSB with 0.5% ropivacaine followed by postoperative RSB with saline or the reverse.  The RSB was performed by a single, experienced anaesthetist and the overall anaesthetic technique was standardised.

The findings showed no significant difference between the visual analogue pain scale rating between the two groups, the time to first use of the PCA pump nor the total opioid requirement at twenty four or forty eight hours postoperatively.  Markers of surgical stress in the form of proinflammatory cytokines were consistently and significantly reduced and BIS data showed a statistically significant improvement in time spent at stage N2 and N3 sleep for those receiving preoperative RSB.

Statistical analysis found that thirty two patients would be needed in each arm for a power of 80% however due to problems with BIS monitoring in two patients, the preoperative RSB group ultimately had thirty patients (thirty two in the postoperative RSB group), leaving the study underpowered overall.

This study is a neat demonstration of the benefit to using preoperative rectus sheath block in open non-cancer gynaecological surgery.  With small numbers leaving the study underpowered and the inclusion of only one type of surgery, further work is needed.

Effective dose of dexmedetomidine as an adjuvant sedative to peripheral nerve blockade in elderly patients. Wang C, Zhang H, Fu Q.

Acta Anaesthesiologica Scandinavia 2018 doi:10.1111/aas.13087

Dexmedetomidine is a relatively new drug with an increasing repertoire for use.  This study assesses the dose required for sedation following peripheral nerve blockade for total knee arthroplasty in older patients.

Forty two patients aged 65 – 85 years were included in the study (two patients were excluded following failure of peripheral nerve blockade and one was excluded due to vomiting affecting the assessment of sedation).  The patients were stratified into two groups – “young-old” aged 65 -74 years and “middle-old” aged 75 – 85 years.  A single calculated dose of dexmedetomidine was administered as a ten minute infusion and the level of sedation assessed using the Observer’s Assessment of Alertness / Sedation Scale.  This was correlated with Bispectral Index (BIS) value alongside usual monitoring parameters.

The dose of dexmedetomidine was adjusted for serial patients based on the previous patient’s reposnse (the Dixon up-down method).  From these data, Effective Dose 50% (ED50) and Effective Dose 95% (ED95) can be determined.

The results showed:

  Young-old Middle-old
ED50 (mcg/kg) 0.57 (0.47 – 0.65) 0.38 (0.28 – 0.46)
ED95 (mcg/kg) 0.76 (0.67 – 1.08) 0.57 (0.48 – 0.89)
BIS50 86 (81 – 91) 85 (84 – 87)
BIS90 72 (53 – 78) 73 (69 – 76)


The ED50 showed increased sensitivity with advancing age, in-keeping with previous studies and the BIS values showed no statistical difference between the age groups.  No patient experienced oxygen desaturation and haemodynamic monitoring showed a modest reduction in heart rate and systolic blood pressure without adverse effects.

Limitations of the study include the use of midazolam (1mg) and fentanyl (50 micrograms) prior to nerve block as these agents will confound the sedative effect of dexmedetomidine.  The study is limited to a single surgical procedure and anaesthetic technique and the data from this study are therefore not generalisable to other operations or anaesthetic techniques.  The number of patients enrolled is quite small but this study serves an important role for setting a benchmark for single dose dexmedetomidine as a sedative adjunct to peripheral nerve blockade.

Journal Club: 28th February 2018

Evaluation of reliability of MYZONE MZ-3 Heart Rate Monitor: A study for the Future of Telephysiotherapy for Preoperative Prehabilitation in Cancer Patients.

TELEMEDICINE and e-HEALTH 2017;23(4):1-5 doi:10.1089/tmj.2016.0138

Presented by: Dr C Francis


Pre-operative optimisation programs seek to implement a series of interventions to improve and enhance recovery after major surgery. An important aspect of this is the use of exercise programs. The Authors of this paper suggest a major barrier to successful completion of these programs could be inaccessibility of in-hospital supervised exercise programs. There is an increasing abundance of wearable technology, however the accuracy and reliability of commercially available Heart Rate monitors is variable.

Design & Setting

Small, prospective, pilot experiment at single centre in Australia. Small sample (n=7) of young, healthy volunteers without significant medical history and in normal sinus rhythm recruited. Asked to perform increasing intensity effort on exercise bike wearing the MYZONE MZ-3 Heart rate monitor and a clinical 3 lead ECG system. Paired HR measurements to be taken and compared statistically using a Bland Altman plot


Seven young physically active, healthy individuals in normal sinus rhythm (mean age 29.7 years; 5 female, 2 male)


Asked to complete an exercise on static bike of increasing intensity whilst wearing both clinical 3 lead ECG and MYZONE MZ-3 HR monitor.


1,983 data points collected. Of which 55 data points unpaired as loss of contact with MYZONE MZ-3 HR Monitor. Only paired data sets included. Significantly 5 of the 7 participants had their collected data received out of sync, reported as being due to a failure to manually synchronise time on both MYZONE MZ-3 HR and ECG monitors pre test. Authors included this data after retrospective correction of data by aligning out of sync data, moving the sample to the left by 20 seconds. The authors feel this adjustment of data unlikely to cause any clinically significant effects on results.


Using a Bland-Altman plot able to demonstrate a bias of 0.4bpm, and adjusted 95% limits of agreement (95% LOA) to be -4.5 to +5.3 bpm. And a percentage error [95%LOA/mean HR] of 3.6%


MYZONE MZ-3 has an acceptable level of reliability for use in healthy volunteers performing exercise across a wide range of HR. Further studies using a similar methodology are required to validate the use in patients presenting for cancer surgery.


  • Prospective study
  • Appropriate use of statistical analysis to assess reliability and precision of HR monitor.


  • This study had a very small sample size, of healthy, young volunteers. Therefore, this cannot be extrapolated to those awaiting cancer surgery.
  • None of the participants were noted to have any features which may have produced inaccuracy such as arrythmias, obesity, tremor, pacemakers.
  • A static bike was used and so there was minimal movement artifact.
  • 55 data sets were not paired due to the loss of contact with HR monitor and are not included in reliability figures.
  • Perhaps most significantly there is retrospective alteration of the data collected from 5 out of the 7 participants. Whilst the authors claim this is unlikely to have caused significant effects to the results I fail to see how an experiment with aims of assessing precision and accuracy of a piece of equipment can be deemed safe when 5/7 of data sources have been altered retrospectively.
  •  In addition, there was no structured exercise protocol used and no examination of the cost benefit of the intervention.


  • Limited at present.
  • Could be deemed a starting point for a project requiring significant further examination.

Potential for impact

Increasing numbers of wearable technologies are available and being used in the community. There is much competition between devices and price points are changing dramatically as with most tech products. The use of these products could be of great use in prehabilitation of pre-operative patients. There is much scope for further investigation and cost benefit analysis of this and similar products.

Journal Club: 21st February 2018

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial.

JAMA Surgery. Published online June 2017. doi:10.1001/jamasurg.2017.1505

Presented by: Dr B Morris


This study aims to tackle the issue of high rates of post operative delirium (POD) and post operative cognitive dysfunction (POCD) in elderly patients. There is thought to be a high incidence of POD (10-60%) and this is also thought to contribute to POCD, a more permanent alteration of mental state. Both these conditions are associated with disadvantageous features such as increased perioperative morbidity, increased length of stay and ultimately decreased life expectancy and quality of life, so it is a significant problem. The authors aimed to evaluate specifically the perioperative use of an infusion of Dexmedetomidate as this has been shown to improve delirium and cognitive dysfunction in ICU patients.

Design & Setting

A double-blind, randomized, parallel group placebo-controlled trial in 10 centres across the USA over 6 years (2008 – 2014).


Of 404 patients who were initially randomized, 390 made it through to be included in the results of the trial. These were patients selected by the following criteria: Age over 68 (adjusted from 70 in the interest of gaining more numbers), undergoing major (planned 2 day admission) elective non-cardiac surgery under GA. There was a long list of exclusory criteria, including surgical, anaesthetic and patient factors such as intracranial/emergency surgery, planned post operative intubation, life limiting conditions, preexisting cognitive conditions and ASA IV/V.


An infusion of of Dexmedetomidine commenced in the anaesthetic room and continued until 2 hours into recovery, vs placebo of saline.


Primary: Presence of delirium whilst hospitalised or until day 5 post operatively.

Secondary: Post operative cognitive decline up to 6 months post operatively.


The trial was stopped early due to futility and failure to find any difference between the two groups.

Primary outcome:

23 patients from the Dexmedetomidine group (12.2%) and 23 patients from the control group (11.4%) developed post operative delirium (risk ratio, 1.06; 95% CI, 0.79-1.41; P = .77). Interestingly they did isolate some other factors that made POD more likely – namely increased length of surgery, baseline mild cognitive impairment, lower number of educational years and type of surgery, general surgery being the least likely to be associated with POD.

Secondary outcome:

There was found to be no statistically significant difference between the two groups in POCD at either 3 or 6 months.

Unintended adverse events:

Similarly distributed between the two groups, with more bradycardia with the Dexmedetomidine group and slightly more infections, although the overall number of infections was low.


This study contrasted with other work on administration of dexmedetomidine in the postoperative setting of 1 or more days in cardiac and non-cardiac surgical patients, which has shown an improvement in POD.

This study did show some correlation between other factors such as educational level and baseline mild cognitive impairment and POD.

Encouragingly, there was little evidence of POCD in either group, perhaps indicating that although Dexmedetomidine is not beneficial, these patients in general are not at high risk for significant POCD anyway.

Strengths and Weaknesses

The exclusion of so many patients did allow for a more robust scientific analysis of Dexmedetomidine and its effects, as the two groups being compared were homogeneous, however this did limit the study’s usefulness in real terms as it may be in many of these excluded patients interests to have POD decreased, more so than the ‘fitter’ population studied.

Whilst absolute presence of delirium was measured, a weakness of the study is that the number of episodes, severity and consequences i.e. length of stay, etc. were not.


Basically, based on this study, we should not endeavour to provide intraoperative Dexmedetomidine infusions to elderly patients undergoing major non cardiac surgery in an attempt to ameliorate POD/POCD.

Potential for impact

This is a useful piece of research in the full context of Dexmedetomidine and POD, but needs to be taken into consideration with all of the other work done in the surrounding areas of other types of surgeries, other populations and prolonged administration post operatively.

Further research should be directed at the higher risk groups that were excluded from this study, and more far-reaching measures such as improvement in patient outcomes (both clinically objective and subjective), length of stay, financial efiiciency etc. It is also still perfectly reasonable to consider providing post operative Dexmeditomidine infusions to high risk patients in HDU/ICU environments in the absence of deleterious factors.

Journal Club: 6th February 2018

Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery A Randomized Clinical Trial. 

The Journal of the American Medical Association. 2017;318(14):1346–1357 doi:10.1001/jama.2017.14172

Presented by: Dr J Lloyd


Perioperative hypotension is known to be related to post operative organ dysfunction, in particular the heart, lungs, and kidneys.

Patients at high-risk of post operative organ dysfunction are also at an increased risk of mortality.

Hypertension is an increasingly common comorbidity, especially in the elderly population, and it alters the autoregulatory capacity of their brain and kidneys leaving them more vulnerable to ischaemia during an episode of hypotension than organs of normotensive patients. It is thus hypothesised that maintaining a higher systolic blood pressure during surgery, in high risk patients with hypertension, will reduce the risk of post operative organ dysfunction.

Guidelines for critical care have suggested altering haemodynamic targets to premorbid levels in hypertensive patients, but there is no good evidence for the same advice in the operating theatre.

This study aims to determine whether adjusted intraoperative haemodynamic targets in hypertensive patients can reduce the incidence of post operative organ dysfunction, and mortality

Design & Setting

A multi-centre, stratified, parallel control group randomised clinical trial conducted across 9 hospitals in France


Patients over 50, with an ASA classification of II or greater, undergoing surgery with an expected duration of over 2 hours, and with an acute kidney injury risk index of III or higher (see figure below)

JC 6th Feb figure

Figure from: KheterpalS,TremperKK,HeungM,etal. Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set. Anesthesiology. 2009;110(3):505-515.


The patients reference blood pressure was measured preoperatively, and then the two arms of the study were protocolled as follows:

  • Experimental group – a 2.5mg in 250ml noradrenaline infusion was administered peripherally to maintain a systolic blood pressure within 10% of the reference pressure.
  • Control group – 6mg boluses of ephedrine (up to a maximum of 60mg before the use of rescue noradrenaline was permitted) were used to treat any drops in systolic BP below 80mmHg or any more than 40% below the reference pressure.

Other aspects of care were standardised such as:

  • Measurement of BP through a radial arterial line
  • Anaesthetic induction with the use of propofol 2-3 mg/kg, sufentanil 0.2 μg/kg and cis-atracurium 0.15 mg/kg. Inhaled anesthetics used for maintenance of general anesthesia, to a target bispectral index between 40 and 60, in addition to intravenous perfusion of sufentanil at 0.1 to 0.2 μg/kg per hour.
  • Mechanical ventilation with the use of a tidal volume between 8 and 10 ml/kg predicted body weight, with a positive end-expiratory pressure between 5 and 10 cmH2O, an inspired oxygen fraction (FIO2) to maintain oxygen saturation ≥95% and the respiratory rate adjusted to maintain end-tidal carbon dioxide concentration between 30-35 mmHg.
  • Blood transfusion to maintain hemoglobin level at greater than 10 g/dl.
  • Core temperature maintained at 37°C.


Primary outcome is a composite measure that includes both meeting the SIRS criteria, as well as demonstrating major organ dysfunction from either the cardiovascular, respiratory, renal, neurological, or coagulation systems within 7 days of the operation.

Secondary outcomes included

  • Intraoperative blood pressure variability, blood loss volume, transfusion requirement, fluid requirements, and rescue vasopressor therapy, as well as incidence of either hypotension, hypertension, or bradycardia
  • Post operative urine output, RIFLE score, requirement for renal replacement, SOFA score, duration of ICU and hospital stay, as well as a wide range of specified postoperative complications within 30 days


The primary outcome event incidence was 38.1% in the treatment group and 51.7% in the control group, this gave an adjusted relative risk of 0.73 with 95% CI of 0.56 to 0.94; P = .02

Of the secondary outcomes:

  • Renal dysfunction occurred in 32.7% in the treatment group Vs 49% in the control group (adjusted relative risk 0.70 with 95% CI of 0.53 to 0.92; P = .01)
  • Altered neurological function occurred in 5.4% of the treatment group Vs 15.9% of the control group (adjusted relative risk, 0.34; 95% CI, 0.16 to 0.75; P = .007)


Individualised targeting of systolic blood pressure in high risk patients reduces the risk of both post operative renal and neurological dysfunction


  • Adequately powered, well designed randomised control study, with clear inter group standardisation of care
  • A clinically relevant question


  • The two regimes use two different vasopressors to attain their haemodynamic goals, so it is possible that some of the difference in outcomes could be from a pharmacological rather than haemodynamic difference.
  • Reference values for preoperative blood pressure values may not always be available in clinical practice for example with emergency surgery.
  • Necessary lack of intervention blinding for the anaesthetists delivering care
  • HES boluses to achieve maximal cardiac index is no longer standard practice, although it was the same protocol in both groups
  • Large numbers of patients were excluded based on their risk score for post operative renal impairment, which means we cannot extrapolate the results to answer the question about how this majority of patients should be treated


  • In cases of expected prolonged surgery, where patients are known to be at risk of post operative renal dysfunction, maintaining systolic pressures of within 10% of their baseline will decrease the risk of post operative renal and neurological dysfunction.
  • It also demonstrates the safety of peripheral dilute noradrenaline, as no adverse outcomes were reported

Potential for impact

Widespread application of the conclusions has the potential to reduce morbidity in a high risk patient group

February 2018

Written by Dr. C. Williams

Comparison of 4 cardiac risk calculators in predicting postoperative cardiac complications after non cardiac operations. Cohn S, Ros NF. The American Journal of Cardiology 2017 doi:10.1016/j.amjcard.2017.09.031

Identifying patients who are at high-risk of perioperative complications is something that we are still trying to refine. There are many risk calculators available to try to identify all kinds of risk – ranging from cardiovascular risk, risk of acute kidney injury, risk of post-operative cognitive dysfunction, risk of mortality and so on. Trying to work out which is the best risk calculator to use can seem like trying to negotiate your way through a minefield.

We know that cardiovascular complications after non cardiac surgery are an important cause of postoperative morbidity and mortality. One can use different risk calculators and get different estimates of the patients risk but which is the most reliable risk predictor? This is a question this paper tries to answer by looking at 4 different cardiac risk calculators.

Trying to identify high risk patients is not a new phenomenon – the first cardiac risk index was published by Goldman et al. in 1977. This was followed in 1999 by Lee at al publishing the revised cardiac risk index (RCRI). In 2013 Davies et al. improved prediction using a 5 factor reconstructed RCRI (R-RCRI). The 2014 ACC/AHA guidelines on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery recommended using the RCRI or two newer tools created from the National Surgical Quality Improvement Program (NSQIP) database – namely the myocardial infarction or cardiac arrest (MICA) calculator or the American College of Surgeons surgical risk calculator (ACS-SRC).

Essentially this paper found that all 4 risk calculators performed well at defining low and elevated risk groups but tended to slightly underestimate cardiac events. There are two salient points made:

  1. The definitions for outcomes and timeframes used to develop the risk calculators are different therefore a valid direct comparison of outcomes is not possible
  2. If the risk calculators are used in a manner different from the way derived they do not perform as well

Ultimately risk calculators give an estimate of risk – it is not a black/white answer as to whether that patient will develop that particular complication. What they are useful for is to facilitate shared decision making discussions with patients and enable them to make an informed decision regarding their treatment choice.

Postoperative ERAS interventions have the greatest impact on optimal recovery: Experience with implementation of EAS across multiple hospitals. Aarts M, Rotstein O, Pearsall E metal on behalf of the iERAS group. Annals of Surgery 2018 doi:10.1097/SLA.0000000000002632 

ERAS (Enhanced recovery after surgery) pathways use evidence-based practices to minimise perioperative stress and promote early recovery. These multimodal care pathways incorporate multiple interventions within the preoperative, intraoperative and postoperative course of the patient’s perioperative journey. Multiple papers have been published which demonstrate that ERAS benefits patients when compared to standard care and show a decreased rate of complications, accelerated recovery and earlier discharge from hospital.

But while ERAS has been shown to be effective at improving outcomes, it can be difficult to implement not least because it requires a sustained collaborative effort from members of a multidisciplinary team. This paper aims to determine which component of ERAS has the largest impact on recovery for patients undergoing colorectal surgery and also to look at the relative benefits of ERAS in laparoscopic versus open surgery.

Of the 2876 patients studied only 20.1% had care that was compliant with all phases of the pathway. The poorest compliance was for the postoperative interventions yet these were the interventions most strongly associated with an optimal recovery. Compliance with ERAS was associated with improved outcomes regardless of whether surgery was open or laparoscopic. However, the impact of ERAS compliance was significantly greater in patients having open surgery.

In addition to the ERAS components two other potentially modifiable factors were found to significantly impact on patient outcomes namely operative technique and preoperative haemoglobin levels.

Maybe it is time to go back and reassess how ERAS is implemented. My view as an anaesthetist is that it seems that more emphasis is placed on the preoperative and intraoperative parts of the pathway – the question is whether this is because that is what happens or because those are the parts of the pathway that anaesthetists are more involved with? There is plenty of emerging evidence that postoperative care is as important as other parts of the pathway and if the results of this study are valid then it would seem that postoperative interventions make the most difference to patient outcomes. Once again this paper adds to the increasing body of evidence that as anaesthetists it may have come to the time that we need to step up to the mark and pay more attention to postoperative care. After all, why take so much care making sure our patients are as pre-optimised as possible and given the best intraoperative care if we do not follow this through to the postoperative phase?

Preoperative geriatric assessment and tailored interventions in frail older patients with colorectal cancer: a randomised controlled trial. Ommundsen N, Wyller TB, Nesbakken A et al. Colorectal Disease 2018 doi:10.111/codi.13785

The role of comprehensive geriatric assessment for older patients undergoing surgery is much discussed in the literature at the moment. Geriatric assessment and input has already been shown to make a difference and improve functional status in hip fracture patients. This paper aimed to looks at whether a preoperative geriatric assessment can identify older patients at risk of developing postoperative complications after surgery for colorectal cancer. Patients over the age of 65 years scheduled for elective colorectal cancer surgery and fulfilling criteria for frailty were randomised to either a preoperative geriatric assessment and a tailored intervention (based on the assessment) or usual care.

The findings of this paper were that a geriatric assessment and tailored intervention made no difference to the rate of complications or to the secondary endpoints of median length of stay, discharge to own home, need for readmittance or reoperation within 30 days or 30 day and 3 month mortality.

In my opinion there are significant limitations to the data in this study – despite running for a long period of time (2011 – 2014) only 122 patients were recruited and consequently the study is probably underpowered (acknowledged by the authors). Also, the optimal time from intervention to surgery was hypothesised to be 3 weeks – which seems a short time period for an intervention to make a significant difference to outcome. Furthermore the authors go on to detail that the actual time for pre optimisation was a median of 6 days. Additional evidence is needed to be able to draw conclusions as to the effectiveness of geriatric assessment on patient outcomes particularly given that geriatric input has been shown to be efficient in other surgical settings.

Does goal-directed haemodynamic and fluid therapy improve peri-operative outcomes? A systematic review and meta-analysis. Chong MA, Wang Y, Berbenetz NM, McConchie I. European Journal of Anaesthesiology 2018;35:1-15 doi:10.1097/EJA.0000000000000778 

There is much debate about the effectiveness of perioperative goal-directed haemodynamic and fluid therapy. The seminal study by Shoemaker et al published in 1988 demonstrated that patients receiving preoperative haemodynamic optimisation titrated to goals of end organ blood flow had improved outcomes. Since then there have been multiple randomised controlled trials looking at this. In my personal experience many anaesthetists have quite polarised views on the efficacy of goal directed therapy.

The authors carried out a systematic review and meta analysis of 95 randomised controlled trials where goal directed therapy was studied defined as fluid and/or vasopressor therapy titrated to haemodynamic goals. The findings of this comprehensive review demonstrate that goal directed therapy modestly improves mortality in non-trauma and non pregnant adult surgical patients. The authors suggest that based on the articles included for analysis, the numbers suggest tat for every 1000 patients treated with goal directed therapy, 18 deaths would be prevented.

However, the quality of evidence was low to very low with much clinical heterogeneity among the goal-directed therapy devices and protocols. This is likely to be an area of continuing interest for perioperative research and further well designed and adequately powered trials are needed. Hopefully the OPTIMISE-II and FLO-ELA trials may answer some of the questions surrounding goal directed therapy.

Clinical guideline and recommendations on pre-operative exercise training in patients awaiting major non-cardiac surgery. New GA, Ayyash R, Danjoux GR. Anaesthesia 2018 doi:10.1111/anae.14177

Pre-operative exercise has been much debated over the past few years. There have been several systematic reviews on the effects of pre-operative exercise with sufficient clinical trial data to support pre-operative exercise training as being safe and efficacious. But how exactly can one translate the evidence from clinical trials into clinical practice. This paper aims to provide practical and evidence-based guidelines on how to deliver pre-operative exercise training to patients awaiting major, non cardiac surgery.

Chronic physical inactivity accelerates age-associated declines in maximal aerobic capacity and functional fitness which consequently places individuals at increased risk of complications when undergoing major or complex surgery.

There are ten key recommendations which cover patient selection for exercise training in surgical patients, integration of exercise training into multi-nodal prehabilitation programmes and advice on exercise prescription factors and follow-up. This guideline also touches on the fact that successful implementation of rehabilitations programmes may prove challenging. A range of institutionalised cultural and attitudinal barriers exist that could affect pre-operative initiatives to a varying degree. System-related barriers include lack of educational opportunities highlighting the benefits of exercise, insufficient infrastructure and concerns about the feasibility of delivery and cost effectiveness of potential programmes. Several barriers to implementation are highlighted – the main ones being resistance to change from patients and staff and lack of funding or support from management.

Although the authors acknowledge that further research is needed to identify the optimal exercise prescription, this is a much needed clinical guidelines. Hopefully it will result in perioperative teams being able to incorporate pre-operative exercise training for patients into their routine practice.

Association between handover of anesthesia care and adverse postoperative outcomes among patients undergoing major surgery. Jones PM, Cherry RA, Allen BN et al. The Journal of the American Medical Association 2018;319(2):143-153 doi:10.1001/jama.2017.20040

This article looked at over 313000 patients to look at whether handing over of care from one anaesthetist to another during surgery is associated with a worse outcome. Given the shift work that many anaesthetists (particularly trainees) now work, handing over of care during surgery cannot always be avoided. Handovers may be temporary (initial clinician hands over care to another clinician for a break and then returns) or complete (care is completely handed over to another clinician). Handover is a potentially vulnerable time for the patient because all information required must be transferred between clinicians in a busy environment with many distractions. If crucial details are missed the patient may be at risk of an adverse event. The alternative theory is that a rested clinician taking over care from a fatigued clinician may improve the quality of care and reduce adverse events.

Complete intraoperative handover of care compared with no handover of care was associated with a higher risk of all-cause death, hospital readmission and major postoperative complications over 30 days (44% versus 29%). Intraoperative handovers were also associated with an increase in intensive care admissions and a longer hospital stay.

This is a topic which raises many questions. The authors note that in Canada the number of complete handovers of care is increasing each year. Fatigue and the effects that it has on performance at work is also much debated at the moment.* Knowing that fatigue exacerbates many human limitations, some departments have implemented policies of restricted duty hours for medical staff. It is likely that these policies have an impact on the number of handovers of care.

Given the increase in adverse events observed in this study, the public health implications are concerning. The most prudent approach would be to minimise unnecessary anaesthetic handovers. However the factor of fatigue cannot be ignored. At some point fatigue will have a measurable and detrimental effect on clinicians and handovers in this case would be reasonable. But the question of how to determine when the risk of a fatigued clinician exceeds the potential risk of a complete handover is not one that can currently be answered.

(*July 2017A national survey of the effects of fatigue on trainees in anaesthesia in the UK.  McClelland L, Holland J, Lomas J-P, Redfern N, Plunkett E. Anaesthesia 2017 doi:10.1111/anae.13965)

Journal Club: 30th January 2018

Assessing the accuracy of algorithm-derived cardiorespiratory fitness in surgical patients: a prospective cohort study. Canadian Journal of Anesthesiology 2017;64:361–369 doi: 10.1007/s12630-017-0812-5

Presented by:  Dr Owen Lewis


  • Widely appreciated that assessing cardiorespiratory fitness pre operatively is useful for estimating perioperative risk
  • Cardiopulmonary exercise testing (CPEX) is seen as gold standard test of cardiorespiratory fitness; however, it’s not practical for all patients to undergo CPEX testing.
  • The authors postulate that an algorithm which calculates a patients MET value based on: height, weight, waist circumference, resting HR, smoking status, and self reported fitness level will provide similar results to MET values calculated from the same patients 6 minute walk test (6MWT) and Duke Activity Status Index (DASI) and therefore be a more accurate way of quantifying cardiorespiratory fitness than simply asking how many flights of stairs they can climb

Design & Setting

  • Prospective cohort study
  • Two Tertiary hospitals in Alberta Canada


  • Patients undergoing major elective surgery between May and September 2015 at above 2 hospitals.
  • Exclusion criteria:
    • ASA 1 or 2
    • Age <45
    • Blood pressure >180/110
    • Unstable angina
    • MI within last month
    • Heart rate >120
    • Taking B blockers
    • Going to be admitted to ITU post operatively
    • Physical or mental disability such that could not perform 6MWT


  • All patients meeting inclusion criteria had there MET value calculated using the trial algorithm, 6MWT and DASI questionnaire.


  1. Correlation between trial algorithm MET score and 6MWT MET score
  2. Correlation between trial algorithm MET score and DASI MET score
  3. Correlation between trial algorithm MET score and 6MWT distance covered


  • Trial algorithm and 6MWT MET score were highly correlated (Pearson R = 0.870, P <0.001)
  • Trial algorithm and DASI MET score were loosely correlated (Pearson R = 0.252, P <0.001)
  • Trial algorithm and distance walked in 6MWT were moderately correlated (Pearson R = 0.420, P<0.001)


  • Strong correlation between trial algorithm and 6MWT and as such could be considered as an alternative.
  • The fact that they excluded patients on B blockers meant low prevalence of heart disease in sample, limiting genralisability of results.
  • Their data suggests that DASI may over estimate cardiorespiratory fitness in those with a low 6MWT, but the number of patients with a low 6MWT in this study was very small and previous bigger studies have shown good correlation
  • There was no attempt in this paper to correlate calculated MET values with post operative outcomes
  • Further evaluation of this algorithm is warranted


  • Attempts to answer a useful question
  • Prospective design
  • Seems adequately powered to demonstrate their outcome measure


  • Effectively a single site study
  • Exclusion criteria significantly limit generalizability particularly excluding patients on B blockers
  • Half of those that met inclusion criteria declined to be in study, is this because they didn’t want a 6MWT and were less fit?
  • Didn’t compare their algorithm to CPEX (gold standard) and also didn’t compare to “current practice” i.e. just asking about flights of stairs or similar


  • Cannot apply study result to average set of patients seen preoperatively in the UK
  • No evidence as yet that MET score calculated this way is as accurate as CPEX or that it correlates to post operative outcomes and as such aids post op planning.

Potential for impact

Very limited impact at present but could be further evaluated in studies




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